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In vivo experiments require appropriate formulations. Research programs are full of examples where drug PK profiles, tolerance, oral bioavailability or efficacy results have significantly been biased because of poor dosing vehicles or protocols.
Because in vivo experiments are so critical for project teams to make relevant decisions, they have to be conducted right the first time. Drugabilis therefore designs and characterises formulations that are adapted to the compound physicochemical profile, the animal model physiology and the route of administration, in order to achieve the specific objectives of each experiment.
We are committed to work on minimal API amount and to meet very short deadlines. Depending on the selected formulations and animal models, we may suggest modifications to optimise the dosing protocols and secure the study outcome. At request, we may also assist our customers in deciding what study to be performed as well as in interpreting the study findings.
More generally we can behave, for all supported programs, as a remote early formulation support group*, designing, manufacturing and shipping well-characterised and ready-to-use samples for any routine or pivotal in vivo study.
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* Typical research formulation support includes:
- IV/PO formulations for PK studies,
- Unusual routes of administration,
- Unusual animal models... |
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